DIDS inhibition of sarcoplasmic reticulum anion efflux and calcium transport.
نویسندگان
چکیده
منابع مشابه
Control of calcium efflux from sarcoplasmic reticulum vesicles by external calcium.
Factors modifying calcium efflux from rabbit skeletal muscle sarcoplasmic reticulum vesicles were examined after phosphate-supported calcium uptake reached steady state. Increasing external Ca”+ promoted calcium efflux by a mechanism that exhibited Michaelis-Menten kinetics; V,,, at 25” with 5 mM MgATP as substrate and 50 mM phosphate as calcium-precipitating anion was -400 nmol/mg/min and the ...
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DIDS (4,4'-di-isothiocyanostilbene-2,2'-disulfonate), an anion channel blocker, triggers Ca2+ release from skeletal muscle SR (sarcoplasmic reticulum). The present study characterized the effects of DIDS on rabbit skeletal single Ca2+-release channel/RyR1 (ryanodine receptor type 1) incorporated into a planar lipid bilayer. When junctional SR vesicles were used for channel incorporation (native...
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ورودعنوان ژورنال:
- Annals of the New York Academy of Sciences
دوره 358 شماره
صفحات -
تاریخ انتشار 1980